DR2313

SKU: orb1305823

Description

DR2313 is a potent and competitive inhibitor of PARP-1 and PARP-2, exhibiting IC50 values of 0.20 µM and 0.24 µM, respectively. Its neuroprotective properties make it a valuable research tool for studying DNA damage response and cell death mechanisms in models of neurological disorders, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 284028-90-6
• MW: 182.24
• Purity: 99.84%
• Formula: C₈H₁₀N₂OS
• SMILES: Cc1nc(=O)c2CSCCc2[nH]1
• Target: PARP
• Solubility: H2O:9.1 mg/mL (49.93 mM);DMSO:18.33 mg/mL (100.58 mM)

Bioactivity

• Target IC50:
  PARP2:0.24 μM|PARP1:0.20 μM
• In Vivo:
  In both permanent and transient focal ischemia models in rats, pretreatment with DR2313 (10 mg/kg i.v. bolus and 10 mg/kg/h i.v. infusion for 6 h) significantly reduced the cortical infarct volume. To determine the therapeutic time window of neuroprotection by DR2313, the effect of post-treatment was examined in transient focal ischemia model and compared with that of a free radical scavenger, MCI-186 (3-methyl-1-phenyl-2-pyrazolone-5-one). Pretreatment with MCI-186 (3 mg/kg i.v. bolus and 3 mg/kg/h i.v. infusion for 6 h) significantly reduced the infarct volume, whereas the post-treatment failed to show any effects. In contrast, post-treatment with DR2313 (same regimen) delaying for 2 h after ischemia still prevented the progression of infarction. These results indicate that DR2313 exerts neuroprotective effects via its potent PARP inhibition, even when the treatment is initiated after ischemia. Thus, a PARP inhibitor like DR2313 may be more useful in treating acute stroke than a free radical scavenger.
• In Vitro:
  DR 2313 decreases neuronal cell death in models of cerebral ischemia in vivo and in vitro.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DR 2313, DR2313, DR-2313, ischemic, inhibit, PARP, PARP2, PARP1, neuroprotective, Inhibitor, poly(ADP-ribose), poly ADP ribose polymerase, polymerase

Compound Identifiers

PubChem CID

135522417