DprE1-IN-25

SKU: orb1226054

Description

A potent, noncovalent DprE1 inhibitor with IC50 of 43 nM, shows activity against Mycobacterium tuberculosis (Mtb) in vitro with MIC of 0.39 uM.

Key Properties

• CAS Number: 1615713-87-5
• MW: 368.4329
• Purity: >98% (HPLC)
• Formula: C₁₉H₂₄N₆O₂
• SMILES: O=C(C1=CN(CC2=NC=NC(N(C)C)=C2C)C3=CC(C)=CN=C31)NCCO
• Target: Antibacterial
• Solubility: DMSO: ≥ 33 mg/mL

Bioactivity

• In Vivo:
  DprE1-IN-2 (compound 18; oral; 100 mg/kg) has t1/2 of 0.9 hours and Cmax of 70 μM in BALB/c Mice. Animal model: BALB/c Mice. Dosage: 100 mg/kg. Administration: Oral. Result: Had t1/2 of 0.9 hours and Cmax of 70 μM.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

MDK3875 | MDK-3875 | MDK 3875 | DprE1-IN-2 | DprE1IN2

Quick Database Links

Gene Symbol

Antibacterial