DPN

SKU: orb1299631

Description

DPN (Diarylpropionitrile) is a selective ERβ agonist used to investigate the distinct roles of estrogen receptor subtypes. It is a valuable research tool for in vitro and in vivo studies in neuroscience, endocrinology, and oncology, particularly for exploring ERβ-mediated pathways in inflammation, neuroprotection, and cancer.

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 1428-67-7
• MW: 239.27
• Purity: 99.01%
• Formula: C₁₅H₁₃NO₂
• SMILES: Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
• Target: Autophagy,Estrogen/progestogen Receptor,Apoptosis,Estrogen Receptor/ERR
• Solubility: DMSO:127.5 mg/mL (532.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.36 mM)

Bioactivity

• Target IC50:
  ERβ:0.85 nM (EC50)
• In Vitro:
  DPN exhibits a 70-fold higher relative binding affinity for ERβ (18%) versus ERα (0.25%), about 80-fold higher transcriptional potency (EC50 = 0.85 nM versus 66 nM), and 170-fold higher relative potency (4.6% versus 0.025%) in transcription assays

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

beta, disease, DPN, Diarylpropionitrile, behaviors, amyloid, anxiety-like, anti-inflammation, antioxidant, Autophagy, Apoptosis, Alzheimer's, Estrogen Receptor/ERR, EstrogenReceptor, estrogen, Estrogen Receptor, ERβ, ERR, Inhibitor, inhibit, neuroprotection, receptor, progestogen Receptor, peptide, progestogenReceptor

Compound Identifiers

PubChem CID

102614