DPBQ

SKU: orb1710791

Description

DPBQ (ZINC1620467) is a p53-activating small molecule that induces apoptosis specifically in polyploid cells. Its mechanism is distinct from topoisomerase inhibition or direct DNA binding. This compound serves as a research tool for studying p53 pathways in oncology, with applications in both in vitro and in vivo models of polyploidy-related diseases.

Research Area

Cell Biology

Key Properties

• CAS Number: 7029-89-2
• MW: 362.38
• Purity: 98.73% (May vary between batches)
• Formula: C₂₄H₁₄N₂O₂
• SMILES: O=C1c2ccccc2C(=O)c2nc(-c3ccccc3)c(nc12)-c1ccccc1
• Target: MDM-2/p53,Apoptosis,p53
• Solubility: DMSO:2.5 mg/mL (6.9 mM)

Bioactivity

• In Vitro:
  DPBQ induces apoptosis and death and selectively affects 4N cells.DPBQ can specifically induce the expression and phosphorylation of p53.Deletion of TP53 can restore the proliferation of tetraploid cells in the presence of DPBQ.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DPBQ, 2,3-Diphenylbenzo[g]quinoxaline-5,10-dione, p53, ZINC 1620467, ZINC1620467, ZINC-1620467

Compound Identifiers

PubChem CID

364074