Doxycycline monohydrate

SKU: orb1685406

Description

Doxycycline monohydrate is a broad-spectrum tetracycline antibiotic that also acts as a metalloproteinase (MMP) inhibitor. It is widely used in research to study MMP-mediated processes in vitro and in models of cancer, inflammation, and tissue remodeling.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 17086-28-1
• MW: 462.4
• Purity: 99.97% (May vary between batches)
• Formula: C₂₂H₂₆N₂O₉
• SMILES: O.C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C2C(=O)c2c(O)cccc12
• Target: Antibiotic,MMP,Parasite,Antibacterial
• Solubility: DMSO:50 mg/mL (108.13 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.81 mM)

Bioactivity

• In Vivo:
  Doxycycline treatment inhibits the activity of tissue MMP and attenuates the decrease in the collagen content in aortas of mice haploinsufficient for collagen III, as well as prevents the development of stress-induced vessel pathology. Doxycycline merits clinical testing as a treatment for vEDS.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Doxycycline, Doxycycline monohydrate, Doxycycline Monohydrate, Antibiotic, Bacterial, inhibit, Inhibitor, Parasite, MMP, Matrix metalloproteinases

Compound Identifiers

PubChem CID

54684461