Doxifluridine

SKU: orb1308065

Description

Doxifluridine

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 3094-09-5
• MW: 246.19
• Purity: 99.86%
• Formula: C₉H₁₁FN₂O₅
• SMILES: O[C@H]1[C@@H](O[C@H](C)[C@H]1O)N2C(=O)NC(=O)C(F)=C2
• Target: Nucleoside Antimetabolite/Analog,DNA/RNA Synthesis
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:45 mg/mL (182.79 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:2.5 mg/mL (10.15 mM);DMSO:55 mg/mL (223.4 mM)

Bioactivity

• In Vivo:
  Metronomic Doxifluridine alone significantly suppresses tumor growth compared with the untreated (control) group, while metronomic Doxifluridine in combination with TNP-470 significantly inhibits tumor growth compared with each treatment alone in in FU-MMT-1 xenografts. Doxifluridine in combination with TNP-470 also leads to a significant reduction of intratumoral vascularity. Doxifluridine significantly inhibits the growth of KPL-4 tumors, reduces the tissue levels of IL-6, and alleviates body weight loss in nude mice bearing KPL-4 tumors. Doxifluridine results in a significant reduction in the activity of phenytoin p-hydroxylation in rats. Doxifluridine decreases the elimination rate constant and the total clearance in rats.
• In Vitro:
  Doxifluridine suppresses tube formation of HUVEC and vascular endothelial growth factor production by FU-MMT-1 cells. Doxifluridine is converted to 5-FU and subsequently to FdUMP, and the results suggest that Doxifluridine exerts its cytotoxic effects through inhibition of TS and incorporation into RNA. Doxifluridine is a fluoropyrimidine derivative that is activated preferentially in malignant cells by thymidine phosphorylase to form 5-fluorouracil (5-FU). Doxifluridine is developed to improve the therapeutic index of 5-FU and to reduce toxicity, including the immunosuppressive, myelosuppressive, and cardiotoxic effects of 5-FU and other fluorinated pyrimidines.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Analog, AMC 0101, AMC0101, AMC-0101, 5'-DFUR, 5-Fluoro-5'-deoxyuridine, DNA Synthesis, DNASynthesis, Doxifluridine, Inhibitor, NucleosideAntimetabolite, Nucleoside Antimetabolite/Analog, Nucleoside Antimetabolite, inhibit, Thymidine phosphorylase, Ro 21-9738, RNASynthesis, RNA Synthesis

Compound Identifiers

PubChem CID

18343