Doxapram hydrochloride hydrate

SKU: orb1310995

Description

Doxapram hydrochloride hydrate is a potent inhibitor of TASK channel subtypes, with EC50 values of 410 nM for TASK-1, 9 µM for TASK-1/TASK-3 heterodimers, and 37 µM for TASK-3. This small molecule is a valuable research tool for studying the role of TASK channels in respiratory control, neuronal excitability, and cellular physiology in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 7081-53-0
• MW: 432.99
• Purity: 99.64%
• Formula: C₂₄H₃₃ClN₂O₃（C₂₄H₃₀N₂O₂·ClH·H₂O）
• SMILES: Cl.CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1
• Target: Potassium Channel
• Solubility: Ethanol:2 mg/mL (4.62 mM);H2O:23 mg/mL (53.12 mM);DMSO:81 mg/mL (187.07 mM)

Bioactivity

• Target IC50:
  TASK3:37 μM(EC50)|TASK1 (heterodimeric channel):9 μM(EC50)|TASK1:410 nM(EC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Doxapram HCl, Doxapram hydrochloride, Doxapram Hydrochloride, Doxapram hydrochloride hydrate, Doxapram hydrochloride Hydrate, Doxapram hydrochloride monohydrate, Doxapram hydrochloride Monohydrate, Inhibitor, KcsA, inhibit, PotassiumChannel, Potassium Channel, TASK-1, TASK-1/TASK-3 heterodimeric, TASK-3

Compound Identifiers

PubChem CID

64647