Dorzagliatin

SKU: orb1308371

Description

Dorzagliatin (HMS5552) is a dual-acting glucokinase activator investigated for type 2 diabetes research. It enhances glycemic control and β-cell function, with studies demonstrating its efficacy in both in vitro enzymatic assays and in vivo animal models of diabetes.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1191995-00-2
• MW: 462.93
• Purity: 99.74% (May vary between batches)
• Formula: C₂₂H₂₇ClN₄O₅
• SMILES: CC(C)C[C@H](N1CC(Oc2ccccc2Cl)=CC1=O)C(=O)Nc1ccn(C[C@@H](O)CO)n1
• Target: Glucokinase
• Solubility: DMSO:125 mg/mL (270.02 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.64 mM)

Bioactivity

• In Vivo:
  In diabetic rats, Dorzagliatin (low-dose 10 mg/kg, and high-dose 30 mg/kg; administered intragastrically; daily 8:00 AM for one month) shows a glucose-lowering effect on the glucose levels.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

glycaemic, Glucokinase, Hexokinase D, Hexokinase IV, HMS-5552, HMS 5552, HMS5552, pancreatic, Inhibitor, inhibit, Dorzagliatin, diabetes, β-cell, type 2

Compound Identifiers

PubChem CID

57920094