Doripenem monohydrate

SKU: orb1309982

Description

Doripenem monohydrate

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 364622-82-2
• MW: 438.52
• Purity: 98.56%
• Formula: C₁₅H₂₄N₄O₆S₂·H₂O
• SMILES: N12C(=C([C@@H]([C@@H]2[C@H](C1=O)[C@@H](C)O)C)S[C@H]1C[C@H](NC1)CNS(=O)(=O)N)C(=O)O.O
• Target: Antibacterial,Antibiotic
• Solubility: DMSO:34 mg/mL (77.53 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (5.7 mM);H2O:24 mg/mL (54.73 mM)

Bioactivity

• In Vitro:
  Doripenem is active against Aeromonas (MIC50, 0.03 mg/L), Bacillus spp. (MIC50, 0.03 mg/L) and all tested anaerobic species (MIC range, < or =0.015-4 mg/L), but is less active against S. maltophilia (MIC90, >32 mg/L) and Enterococcus faecium (MIC90, >32 mg/L) among the enterococcal species. Doripenem is the most active carbapenem (MIC90, 1 to 4 mg/mL) against penicillin-resistant streptococci. Doripenem is found to be highly active against oxacillin-susceptible Staphylococcus aureus and coagulase-negative staphylococci (2705 and 297 isolates, respectively; MIC90s 0.06 mg/L), with a potency greater than that of other carbapenem antibiotics. Doripenem is among the most potent agents tested against Streptococcus pneumoniae, viridans group streptococci and beta-haemolytic streptococci (885, 140 and 397 isolates; MIC(90)s 0.5, 0.5 and 0.03 mg/L, respectively). Doripenem is also active against Citrobacter spp., Enterobacter spp. and Serratia spp. (MIC90s 0.06-0.25 mg/L), including ceftazidime-resistant isolates. Doripenem is slightly more potent (MIC50 2 mg/L) than ertapenem and imipenem (MIC50 4 mg/L), and has a potency similar to that of meropenem (MIC50 2 mg/L), against Burkholderia cepacia (20 isolates). Doripenem demonstrates in vitro activity similar to that of meropenem against gram-negative pathogens and to that of imipenem against gram-positive pathogens.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Doripenem, Doripenem Hydrate, Doripenem monohydrate, Doripenem Monohydrate, Bacterial, Antibiotic, inhibit, Inhibitor, S 4661, S 4661 Monohydrate, S 4661 monohydrate, S4661, S-4661, S4661 Monohydrate, S-4661 Monohydrate

Compound Identifiers

PubChem CID

636377