Dopamine hydrochloride

SKU: orb1819288

Description

Dopamine hydrochloride (ASL279) is a natural catecholamine neurotransmitter that mainly acts on dopamine receptors (D1-5 receptors) (EC50=2.7 nM). Dopamine hydrochloride induces VEGFR2 endocytosis through D2 dopamine receptor and has pro-angiogenic activity.

Research Area

Cell Biology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 62-31-7
• MW: 189.64
• Purity: 99.76%
• Formula: C₈H₁₂ClNO₂
• SMILES: Cl.NCCc1ccc(O)c(O)c1
• Target: 5-HT Receptor,Dopamine Receptor,Ferroptosis,Endogenous Metabolite
• Solubility: DMSO:55 mg/mL (290.02 mM);H2O:19 mg/mL (100.19 mM)

Bioactivity

• Target IC50:
  Amplitude of GABAA IPSCs:3.4 ± 0.8 μM|Arachidonic acid (Release):0.5 nM (CHO cells)|Dopamine D1 receptor:55.5 nM (EC50)|Prolactin release:60 nM|Excitatory postsynaptic currents:12.8 ± 2.8 μM
• In Vitro:
  METHODS: CYP3A4/5, CYP2C19 and CYP2C9 were treated with Resmetirom to detec the Inhibition of cell growth. Results the IC50 of ResmetiromCYP3A4/5 and CYP2C19 were both greater than 50 μM, with no growth inhibitory effect the inhibitory effect on CYP2C9 was relatively weak, an the IC50 was approximately 22 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

proliferation, neurotransmitter, inhibit, Inhibitor, HUVECs, Ferroptosis, EndogenousMetabolite, Endogenous Metabolite, ASL-279, ASL279, ASL 279, catecholamine, 5-HT, 5HTReceptor, 5HT Receptor, DopamineReceptor, Dopamine Receptor, Dopamine HCl, Dopamine Hydrochloride, Dopamine hydrochloride, Dopamine, DA transporter

Compound Identifiers

PubChem CID

65340