Donafenib

SKU: orb1307736

Description

Donafenib is a deuterated analog of the multikinase inhibitor Sorafenib. It potently inhibits Raf-1, B-Raf, and VEGFR-3 kinases, making it a valuable research tool for studying oncogenic signaling pathways in both cellular and animal models of cancer.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1130115-44-4
• MW: 467.84
• Purity: 99.88% (May vary between batches)
• Formula: C₂₁H₁₃ClD₃F₃N₄O₃
• SMILES: [2H]C([2H])([2H])NC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
• Target: FLT,Autophagy,Raf,VEGFR,Ferroptosis,Apoptosis
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.05 mM);DMSO:90 mg/mL (192.37 mM)

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Sorafenib, Sorafenib (D3), Sorafenib-d3, Raf-1, VEGFR3, Bay 43-9006, Bay 43-9006 (D3), B-Raf

Compound Identifiers

PubChem CID

25191001