Dodecane

SKU: orb2279169

Description

Dodecane is a linear alkane solvent and fuel component, also employed as a reference standard. In research, it serves as a model irritant in dermatological studies, where it has been shown to induce TNF-α expression in rat skin in vivo.

Research Area

Cell Biology

Key Properties

• CAS Number: 112-40-3
• MW: 170.33
• Formula: C₁₂H₂₆
• SMILES: CCCCCCCCCCCC
• Target: Others,TNF
• Solubility: DMSO:15 mg/mL (88.06 mM)

Bioactivity

• In Vivo:
  Methods: Hairless rats (CD HrBi rats) were treated with dodecane (230 μL, topical, single dose, 1 hour) to investigate the effects of dodecane on skin irritation (erythema), transepidermal water loss (TEWL), and expression of interleukin-1α (IL-1α), tumor necrosis factor (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) in the skin and blood. Results: Dodecane induced high transepidermal water loss and increased TNF-α expression in the CD HrBi rat model.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ba 51-090453, Dodecane

Compound Identifiers

PubChem CID

8182