DO-264

SKU: orb1709847

Description

DO-264 is a potent and selective inhibitor of the serine hydrolase ABHD12 (IC50 = 11 nM). By blocking cellular lysophosphatidylserine (LysoPS) degradation, this compound enhances LPS-stimulated phagocytosis in vitro, making it a valuable tool for studying neuroimmunology and lysophospholipid signaling pathways.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2301866-59-9
• MW: 558.4
• Purity: 99.95% (May vary between batches)
• Formula: C₂₃H₂₀Cl₂F₃N₅O₂S
• SMILES: FC(F)(F)Oc1ccc(Oc2ccnc(N3CCC(CC3)NC(=S)Nc3cccnc3)c2Cl)c(Cl)c1
• Target: Others,MAGL
• Solubility: DMSO:80 mg/mL (143.27 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.91 mM)

Bioactivity

• Target IC50:
  ABHD12:11 nM
• In Vivo:
  Mice treated with DO-264 exhibited a dose-dependent increase in brain lyso-PS and 20:4 PS content, which qualitatively resembled changes observed in ABHD12(-/-) mice. Additionally, both ABHD12(-/-) and DO-264-treated mice displayed exacerbated immunopathology following infection with the lymphocytic choriomeningitis virus (LCMV) clone 13, resulting in severe inflammatory lung damage, heightened chemokine production, and, in some cases, death..
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• In Vitro:
  DO-264 elevated the lyso-PS and 20:4 PS content of primary human macrophages.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DO 264, DO264, DO-264, ABHD12

Compound Identifiers

PubChem CID

134813646