DNQX

SKU: orb1299937

Description

DNQX (FG 9041) is a selective, competitive antagonist of non-NMDA ionotropic glutamate receptors, demonstrating potent inhibition of AMPA and kainate receptor subtypes. It is widely used in neuroscience research to study excitatory synaptic transmission, neuronal excitability, and the role of these receptors in various neurological models, both in vitro and in vivo.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2379-57-9
• MW: 252.14
• Purity: 97.15% (May vary between batches)
• Formula: C₈H₄N₄O₆
• SMILES: [O-][N+](=O)c1cc2[nH]c(=O)c(=O)[nH]c2cc1[N+]([O-])=O
• Target: iGluR,GluR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.93 mM);DMSO:60 mg/mL (237.96 mM)

Bioactivity

• In Vitro:
  DNQX has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. DNQX does not stimulate a robust long-term potentiation in the hippocampus
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

FG9041, FG-9041, FG 9041, iGluR, Inhibitor, non-NMDA, inhibit, Ionotropic glutamate receptors, nucleus, AMPA, competitive, DNQX, quinoxaline, selective, thalamic, reticular

Compound Identifiers

PubChem CID

3899541