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DNQX

SKU: orb1220510

Description

DNQX is a competitive non-NMDA glutamate receptor antagonist (IC50s = 0.5 and 0.1 μM for AMPA and kainate receptors respectively).

Images & Validation

Key Properties

CAS Number2379-57-9
MW252.14
Purity>98% (HPLC)
FormulaC8H4N4O6
SMILES[O-][N+](=O)c1cc2[nH]c(=O)c(=O)[nH]c2cc1[N+]([O-])=O
TargetGluR
SolubilityDMSO:35 mg/mL (138.81 mM)

Bioactivity

In Vivo
DNQX, a specific AMPA receptor antagonist, given as either a 5 mg/kg or 10 mg/kg intraperitoneal dose or into the lateral cerebral ventricle (5 μl of 0.5 mg/ml) significantly diminishes phencyclidine (PCP) (40 mg/kg) and ketamine (80, 100, 120 mg/kg) hsp70 induction in the posterior cingulate and retrosplenial cortex.
In Vitro
DNQX selectively depolarizes thalamic reticular nucleus (TRN) neurons.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FG 9041

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Protocol Information

DNQX (orb1220510)

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% DMSO +
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