DNMT1-IN-5

SKU: orb2944388

Description

DNMT1-IN-5 (Compound 55) is a dual inhibitor of DNMT1 and DNMT3A with IC50 values of 2.42 μM and 14.4 μM, respectively. It demonstrates broad antiproliferative activity in cancer cell lines, induces cell cycle arrest and apoptosis, and shows in vivo efficacy in a TMD-8 xenograft model.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 2982511-19-1
• MW: 437.556
• Formula: C₂₄H₃₂FN₇
• SMILES: FC1=NC=CC(=C1)C=2N=C(NC3CCN(C)CC3)C=4C=CN(C4N2)CCCN5CCCC5
• Target: Apoptosis,DNA Methyltransferase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

169095346