DNMT-IN-6

SKU: orb3211286

Description

DNMT-IN-6 is a DNA methyltransferase inhibitor effective against DNMT1, DNMT3A, and DNMT3B. It promotes demethylation and restores the expression of the TMS1 tumor suppressor gene. DNMT-IN-6 induces apoptosis, causes G2/M phase arrest, disrupts mitochondrial integrity, and activates endogenous caspase cascades (3/7/9). Additionally, it inhibits tumor growth and enhances survival rates in xenograft models. DNMT-IN-6 is applicable in cancer research, including studies on diffuse large B-cell lymphoma.

Key Properties

• CAS Number: 3038316-36-5
• MW: 447.40
• Formula: C₁₉H₁₈AsNO₃S₂
• SMILES: O=C(C=CC1=CC=C2OCOC2=C1)NC3=CC=C(C=C3)[As]4SCCCS4
• Target: Apoptosis,Caspase,DNA Methyltransferase,Mitochondrial Metabolism

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Caspase,DNA Methyltransferase,Mitochondrial Metabolism