DNA/TOP2A-IN-1

SKU: orb3173269

Description

DNA/TOP2A-IN-1 functions as an inhibitor of DNA and TOP2A. It binds selectively to TOP2A instead of TOP2B and interacts with DNA to form a stable DM1-TOP2A-DNA ternary complex. This compound induces DNA damage, elevates reactive oxygen species (ROS), and triggers apoptosis in triple-negative breast cancer (TNBC) cells. Additionally, DNA/TOP2A-IN-1 disrupts microtubule distribution and induces cell cycle arrest while exhibiting potent antiproliferative activity and inhibiting cell migration. It effectively suppresses tumor growth and is a valuable agent for TNBC research.

Research Area

Cell Biology, Immunology & Inflammation, Molecular Biology, Signal Transduction

Key Properties

• Target: Topoisomerase,Microtubule Associated,ROS,Apoptosis

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Topoisomerase,Microtubule Associated,ROS,Apoptosis