DNA-PK-IN-16

SKU: orb3211002

Description

DNA-PK-IN-16 is an orally active inhibitor of DNA-dependent protein kinase (DNA-PK) with an IC50 of 10.2 nM. It induces an increase in the biomarker γH2A.X associated with DNA double-strand breaks and shows antiproliferative activity in various cancer cell lines. Additionally, DNA-PK-IN-16 can enhance CD8+ T cell infiltration into tumor tissues when used in conjunction with anti-PD-L1 monoclonal antibodies. It is a useful compound for cancer research.

Key Properties

• Target: Apoptosis,DNA-PK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,DNA-PK