DNA-PK-IN-12

SKU: orb2566394

Description

DNA-PK-IN-12 (compound 31t) is a potent, orally bioavailable DNA-PK inhibitor with an IC50 of 0.1 nM. It inhibits Hct116 cell proliferation (IC50 = 33.28 µM) and colony formation in vitro and demonstrates antitumor efficacy in vivo, supporting research in DNA damage response and oncology.

Research Area

Molecular Biology, Signal Transduction

Key Properties

• CAS Number: 2792146-91-7
• MW: 420.47
• Formula: C₂₁H₂₄N₈O₂
• SMILES: O=C1N(C=2C(N1C)=CN=C(NC=3C(C)=CC(=NC3)C4=CN(C)N=C4)N2)C5CCOCC5
• Target: DNA-PK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

164544735