DMU-2139

SKU: orb1298681

Description

DMU2139 is a potent and selective small molecule inhibitor of cytochrome P450 1B1 (CYP1B1), exhibiting an IC50 of 9 nM, with significantly lower activity against CYP1A1 (IC50 795 nM). This inhibitor is a valuable research tool for studying CYP1B1's role in steroid metabolism, chemical carcinogenesis, and in vitro enzyme inhibition assays.

Research Area

Cancer Biology

Key Properties

• CAS Number: 104890-70-2
• MW: 289.33
• Purity: 98.88% (May vary between batches)
• Formula: C₁₉H₁₅NO₂
• SMILES: C(C=CC=1C=CC=NC1)(=O)C2=CC3=C(C=C(OC)C=C3)C=C2
• Target: Cytochromes P450
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.91 mM);DMSO:11 mg/mL (38.02 mM)

Bioactivity

• Target IC50:
  CYP1B1:9 nM|CYP1A1:795 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DMU-2139, DMU 2139, DMU2139, CYP1B1

Compound Identifiers

PubChem CID

73185509