DMH-25

SKU: orb1298824

Description

DMH25 is a novel, covalent, and potent mTOR inhibitor. It demonstrates significant antitumor efficacy in vivo, particularly against triple-negative breast cancer models. This small molecule is a valuable research tool for studying mTOR signaling and oncology in both cellular and animal studies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1685280-21-0
• MW: 489.94
• Purity: 99.26% (May vary between batches)
• Formula: C₁₅H₈Br₃NO₃
• SMILES: N(=O)(=O)C=1C(OC=2C(C1)=CC(Br)=CC2Br)C3=CC=C(Br)C=C3
• Target: mTOR
• Solubility: DMSO:25 mg/mL (51.03 mM)

Bioactivity

• In Vivo:
  In vivo, DHM25 was an efficient inhibitor of growth and metastasis of triple-negative breast cancer cells, paving the way for its clinical application in oncology. Constitutive activation of the PI3K/mTOR signaling pathway contributes to carcinogenesis and metastasis in most, if not all, breast cancers.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

mTOR, DMH 25, DMH25, DMH-25

Compound Identifiers

PubChem CID

91667527