DMH-1

SKU: orb1226800

Description

DMH1 is a potent, selective bone morphogenetic protein receptor (BMP) inhibitor with IC50 of 27/107.9/<5/47.6 nM for ALK1/ALK2/ALK3/ALK6, respectively; significantly reduces the percentage of cells expressing the pluripotency marker proteins OCT4 and Nanog in both SM3 and CA6 cells, induces regulation of pluripotency and neural precursor marker mRNAs; reduces the canonical phosphorylation of Smads 1,5 and 9, inhibits HeLa and MCF-7 cell proliferation; significantly reduces the tumor growth in human lung cancer xenograft model.

Key Properties

• CAS Number: 1206711-16-1
• MW: 380.4418
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₀N₄O
• SMILES: CC(OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1)C
• Target: TGFBR
• Solubility: DMSO: 11.5 mg/mL

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DMH1 | DMH 1

Quick Database Links

Gene Symbol

TGFBR