DM4-SMe

SKU: orb1709855

Description

DM4-SMe is a cytotoxic metabolite of antibody-maytansinoid conjugates (AMCs) and a potent tubulin inhibitor. With an IC50 of 0.026 nM in KB cells, it is a key payload for ADC research, enabling studies on targeted cancer therapy in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 796073-68-2
• MW: 826.46
• Formula: C₃₉H₅₆ClN₃O₁₀S₂
• SMILES: [H][C@@]12C[C@@](O)(NC(=O)O1)[C@]([H])(OC)\C=C/C=C(C)\Cc1cc(OC)c(Cl)c(c1)N(C)C(=O)C[C@]([H])(OC(=O)[C@H](C)N(C)C(=O)CCC(C)(C)SSC)[C@]1(C)O[C@H]1[C@@H]2C
• Target: Microtubule Associated,ADC Cytotoxin

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

155819422