DL-Homocysteine

SKU: orb1221373

Description

DL-Homocysteine is a potential marker for tumor cell growth. increased plasma homocysteine is a risk factor for coronary heart disease and carcinogenesis.

Key Properties

• CAS Number: 454-29-5
• MW: 135.19
• Purity: >98% (HPLC)
• Formula: C₄H₉NO₂S
• SMILES: NC(CCS)C(O)=O
• Target: Endogenous Metabolite
• Solubility: DMSO:10 mM;Water:Soluble

Bioactivity

• In Vivo:
  DL-Homocysteine (1.3 mmol/kg, i.p.) increases KYNA content (pmol/g tissue) from 8.47 ± 1.57 to 13.04 ± 2.86 and 11.4 ± 1.72 in cortex, and from 4.11 ± 1.54 to 10.02 ± 3.08 in rat hippocampus.
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• In Vitro:
  DL-Homocysteine (0.1-0.5 mM) significantly enhances kynurenic acid (KYNA) production in rat cortical slices, and diministes the production of at 3.0, 5.0, and 10.0 mM, with the estimated IC50 of 6.4 (5.5-7.5) mM. DL-Homocysteine dose-dependently inhibits kynurenine aminotransferases I (KATI) activity at concentrations ≥0.2 mM, with an IC50 of 0.566 (0.442-0.724) mM, and the activity of KAT II with IC50 value of 8.046 (5.804-11.154) mM.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

2-Amino-4-mercaptobutyric acid

Quick Database Links

Gene Symbol

Endogenous Metabolite