DL-Buthionine-(S,R)-sulfoximine

SKU: orb1299573

Description

DL-Buthionine-(S,R)-sulfoximine (BSO) is a potent and selective inhibitor of γ-glutamylcysteine synthetase, the rate-limiting enzyme in glutathione biosynthesis. It is widely used in cancer research, both in vitro and in vivo, to deplete cellular glutathione and study oxidative stress mechanisms in solid tumor models.

Research Area

Cell Biology

Key Properties

• CAS Number: 5072-26-4
• MW: 222.31
• Purity: 99.76% (May vary between batches)
• Formula: C₈H₁₈N₂O₃S
• SMILES: CCCCS(=N)(=O)CCC(N)C(O)=O
• Target: Ferroptosis
• Solubility: H2O:31.25 mg/mL (140.57 mM);DMSO:Insoluble

Bioactivity

• In Vivo:
  D,L-Buthionine-(S,R)-sulfoximine (32 mmol/kg, i.p.) reduces renal glutathione in mice without inducing abnormal behavior or convulsions. It has antiparasitic activity, eliminating T. brucei from the bloodstream of infected mice via depletion of intratrypanosomal glutathione and induction of oxidative stress at a dose of 4 mmol/kg.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

γ-glutamylcysteine synthetase, Ferroptosis, Inhibitor, inhibit, NSC 381100, NSC381100, NSC-381100, BSO, Buthionine sulfoximine, Butionine sulfoximine, D,L-Buthionine-(S,R)-sulfoximine, D,L-Buthionine-sulfoximine, DLButhionine(S,R)sulfoximine, DL-Buthionine-sulfoximine, DL Buthionine (S,R) sulfoximine

Compound Identifiers

PubChem CID

21157