DL-AP5

SKU: orb1305831

Description

DL-AP5

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 76326-31-3
• MW: 197.13
• Purity: 99.33%
• Formula: C₅H₁₂NO₅P
• SMILES: C(CC(C(O)=O)N)CP(=O)(O)O
• Target: NMDAR,iGluR
• Solubility: DMSO:Insoluble;H2O:10 mM

Bioactivity

• In Vivo:
  DL-AP5, a competitive nMDAR antagonist, on tramadol state-dependent memory. A Single-trial step-down passive avoidance task was used fo the assessment of memory retrieval in adult Male nMRI mice. Post-training i.p. Administration of an atypical μ-opioid receptor agonist, tramadol (2.5 and 5 mg/kg), dose-dependently induced impairment of memory retention. Pre-test injection of tramadol (2.5 and 5 mg/kg) induced state-dependent retrieval o the memory acquired under post-training administration of tramadol (5 mg/kg) influence. Pre-test intra-CA1 injection of nMDA (10-5 and 10-4 μg/mouse) 5 min befor the administration of tramadol (5 mg/kg, i.p.) dose-dependently inhibited tramadol state-dependent memory. Pre-test intra-CA1 injection of DL-AP5 (0.25 and 0.5 μg/mouse) reverse the memory impairment induced by post-training administration of tramadol (5 mg/kg). Pre-test administration of DL-AP5 (0.25 and 0.5 μg/mouse) with an i effective dose of tramadol (1.25 mg/kg) restore the retrieval and induced tramadol state-dependent memory. It can be concluded that dorsal hippocampal nMDAR mechanisms play an important role in the modulation of tramadol state-dependent memory.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Tonic pain, Retina, Inhibition, Ionotropic glutamate receptors, inhibit, NMDA, Ganglion cells, iGluR, Inhibitor, 2-APV, Antinociceptive activity, DL-AP5, DL-AP-5, DLAP5, DL AP5

Compound Identifiers

PubChem CID

1216