DL-AP5

SKU: orb1305831

Description

DL-AP5 is a racemic mixture that acts as a selective NMDA receptor antagonist. It is widely used in neuroscience research to study excitatory neurotransmission, synaptic plasticity, and mechanisms of epilepsy, with applications in both in vitro electrophysiology and in vivo models of convulsions.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 76326-31-3
• MW: 197.13
• Purity: 99.33%
• Formula: C₅H₁₂NO₅P
• SMILES: C(CC(C(O)=O)N)CP(=O)(O)O
• Target: iGluR,NMDAR
• Solubility: DMSO:Insoluble;H2O:10 mM

Bioactivity

• In Vivo:
  DL-AP5, a competitive NMDAR antagonist, on tramadol state-dependent memory. A single-trial step-down passive avoidance task was used for the assessment of memory retrieval in adult male NMRI mice. Post-training i.p. administration of an atypical μ-opioid receptor agonist, tramadol (2.5 and 5 mg/kg), dose-dependently induced impairment of memory retention. Pre-test injection of tramadol (2.5 and 5 mg/kg) induced state-dependent retrieval of the memory acquired under post-training administration of tramadol (5 mg/kg) influence. Pre-test intra-CA1 injection of NMDA (10-5 and 10-4 μg/mouse) 5 min before the administration of tramadol (5 mg/kg, i.p.) dose-dependently inhibited tramadol state-dependent memory. Pre-test intra-CA1 injection of DL-AP5 (0.25 and 0.5 μg/mouse) reversed the memory impairment induced by post-training administration of tramadol (5 mg/kg). Pre-test administration of DL-AP5 (0.25 and 0.5 μg/mouse) with an ineffective dose of tramadol (1.25 mg/kg) restored the retrieval and induced tramadol state-dependent memory. It can be concluded that dorsal hippocampal NMDAR mechanisms play an important role in the modulation of tramadol state-dependent memory.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tonic pain, Retina, Inhibition, Ionotropic glutamate receptors, inhibit, NMDA, Ganglion cells, iGluR, Inhibitor, 2-APV, Antinociceptive activity, DL-AP5, DL-AP-5, DLAP5, DL AP5

Compound Identifiers

PubChem CID

1216