DL-3-AMINOISOBUTYRIC ACID

SKU: orb1221345

Description

beta-aminoisobutyric acid is the product from the conversion of N-carbamyl-beta-aminoisobutyric acid by the enzyme Beta-ureidopropionase (EC 3.5.1.6) the last step in pyrimidine degradation. Beta-ureidopropionase deficiency is an inborn error of pyrimidine degradation associated with neurological abnormalities.

Key Properties

• CAS Number: 144-90-1
• MW: 103.12
• Purity: >98% (HPLC)
• Formula: C₄H₉NO₂
• SMILES: CC(CN)C(O)=O
• Target: Endogenous Metabolite
• Solubility: DMSO:10 mM

Bioactivity

• In Vivo:
  Weight is slightly decreased in the mice by the end of 3-Amino-2-methylpropanoic acid (BAIBA) treatment. Analysis of body composition using MRI demonstrates BAIBA treatment significantly decreases body fat in the mice. Consistent with the effects on thermogenic and β-oxidation gene expression and body weights, analysis with metabolic cages indicates that oxygen consumption (VO2) and whole body energy expenditure are increased in the BAIBA treated mice without any significant difference in activity or food intake. The mice are also challenged with an intraperitoneal glucose tolerance test (IPGTT). BAIBA is found to significantly improve the glucose tolerance in the mice as determined by the area under the curve of the IPGTT.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

3-Amino-2-methylpropanoic acid | α-Methyl-β-alanine

Quick Database Links

Gene Symbol

Endogenous Metabolite