DKFZ-748

SKU: orb2944185

Description

DKFZ-748 is a selective HDAC10 inhibitor and has a dose-dependent growth inhibitory effect on HeLa cells.

Research Area

Epigenetics & Chromatin, Molecular Biology

Key Properties

• CAS Number: 2490709-68-5
• MW: 329.39
• Purity: 98.10%
• Formula: C₁₈H₂₃N₃O₃
• SMILES: O=C(NCCN(C)CCCC(=O)NO)C1=CC=CC=2C=CC=CC21
• Target: HDAC
• Solubility: DMSO:80 mg/mL (242.87 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.02 mM)

Bioactivity

• In Vitro:
  DKFZ-748 inhibits HeLa cell growth in a dose-dependent manner and induces HDAC acetylation in BE(2)-C cells (1–100 μM, 72 h), with significant effects observed only at the highest concentration (100 μM). DKFZ-748 also causes dose-dependent accumulation of N8-acetyl- and N1,8-diacetylspermidine.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DKFZ748

Compound Identifiers

PubChem CID

155146335