DK419

SKU: orb1308379

Description

DK419 is a potent, orally bioavailable small molecule inhibitor of the Wnt/β-catenin pathway (IC50 = 0.19 µM). It downregulates key oncogenic targets including Axin2, β-catenin, c-Myc, Cyclin D1, and Survivin while activating pAMPK. This inhibitor is a valuable research tool for studying Wnt-driven cancers in both cellular and animal models.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 2102672-22-8
• MW: 407.7
• Purity: 98.15% (May vary between batches)
• Formula: C₁₆H₈ClF₆N₃O
• SMILES: FC(F)(F)c1nc2cc(Cl)cc(C(=O)Nc3ccc(cc3)C(F)(F)F)c2[nH]1
• Target: Wnt/beta-catenin,CDK,c-Myc,AMPK,Survivin
• Solubility: DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  DK419 inhibited the growth of patient derived CRC240 tumor explants in mice dosed orally.
• In Vitro:
  DK419 inhibited the growth of CRC tumor cells in vitro and had good plasma exposure when dosed orally.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Beta catenin, beta-catenin, betacatenin, DK419, DK-419, DK 419, bcatenin, Inhibitor, inhibit, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, Wnt, βcatenin, β-catenin

Compound Identifiers

PubChem CID

44536362