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Dizocilpine

SKU: orb1300929

Description

Dizocilpine (MK-801) is a potent, non-competitive NMDA receptor antagonist with a Kd of 37.2 nM. It blocks the receptor's ion channel to inhibit calcium influx, producing anticonvulsant effects and enabling its use in modeling schizophrenia for neuroscience research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number77086-21-6
MW221.3
Purity99.98% (May vary between batches)
FormulaC16H15N
SMILESC[C@]12C=3C([C@](N1)(CC=4C2=CC=CC4)[H])=CC=CC3
TargetiGluR,NMDAR
SolubilityDMSO:255 mg/mL (1152.28 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (22.59 mM)

Bioactivity

Target IC50
NMDA:30.5 nM(Ki)

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Dizocilpine, anticonvulsant, ambulation, Inhibitor, hyperlocomotion, iGluR, NMDA receptor, neurotransmitter, MK-801, MK801, MK 801, inhibit, noncompetitive, Ionotropic glutamate receptors, voltage

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 160.00
50 mg
$ 240.00
100 mg
$ 340.00
200 mg
$ 500.00
DispatchUsually dispatched within 5-10 working days
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