Dizocilpine

SKU: orb1300929

Description

Dizocilpine (MK-801) is a potent, non-competitive NMDA receptor antagonist with a Kd of 37.2 nM. It blocks the receptor's ion channel to inhibit calcium influx, producing anticonvulsant effects and enabling its use in modeling schizophrenia for neuroscience research.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 77086-21-6
• MW: 221.3
• Purity: 99.75% (May vary between batches)
• Formula: C₁₆H₁₅N
• SMILES: C[C@]12C=3C([C@](N1)(CC=4C2=CC=CC4)[H])=CC=CC3
• Target: iGluR,NMDAR
• Solubility: DMSO:255 mg/mL (1152.28 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (22.59 mM)

Bioactivity

• Target IC50:
  NMDA:30.5 nM(Ki)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dizocilpine, anticonvulsant, ambulation, Inhibitor, hyperlocomotion, iGluR, NMDA receptor, neurotransmitter, MK-801, MK801, MK 801, inhibit, noncompetitive, Ionotropic glutamate receptors, voltage

Compound Identifiers

PubChem CID

180081