Divarasib adipate

• Catalog Number: orb2566403
• Category: Small Molecules
• Description: Divarasib (GDC-6036) adipate is a selective and highly potent KRAS G12C inhibitor with an impressively low IC 50 value of < 0.01 μM, designed for oral administration. It covalently attaches to the switch II (SW-II) pocket in KRAS G12C, irreversibly maintaining the protein in its inactive GDP-bound state [1] [2].
• CAS Number: 2762240-36-6
• Purity: 98.00%
• MW: 768.2
• SMILES: C(CCC(O)=O)CC(O)=O.FC=1C2=C(C(=NC(OCC3N(C)CCC3)=N2)N4C(C)CN(C(C=C)=O)CC4)C=C(Cl)C1C5=C(C(F)(F)F)C(C)=CC(N)=N5
• Formula: C₃₅H₄₂ClF₄N₇O₆
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.