Divarasib adipate

SKU: orb2566403

Description

Divarasib (GDC-6036) adipate is an orally bioavailable, covalent KRAS G12C inhibitor with sub-nanomolar potency (IC50 <0.01 µM). It irreversibly binds the switch-II pocket, locking KRAS in its inactive GDP-bound conformation, and is used in both in vitro biochemical assays and in vivo cancer research models.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2762240-36-6
• MW: 768.2
• Formula: C₃₅H₄₂ClF₄N₇O₆
• SMILES: C(CCC(O)=O)CC(O)=O.FC=1C2=C(C(=NC(OCC3N(C)CCC3)=N2)N4C(C)CN(C(C=C)=O)CC4)C=C(Cl)C1C5=C(C(F)(F)F)C(C)=CC(N)=N5
• Target: Ras,Kras

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

171904568