Disopyramide

SKU: orb1225167

Description

A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties. (In Vitro):HERG tail currents recorded at -40 mV following test pulses to +30 mV were inhibited in a dose-dependent fashion by Disopyramide concentrations within the clinical range (IC50=7.23 μM).

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 3737-09-5
• MW: 339.47
• Purity: >98% (HPLC)
• Formula: C₂₁H₂₉N₃O
• SMILES: O=C(N)C(C1=CC=CC=C1)(CCN(C(C)C)C(C)C)C2=CC=CC=N2
• Target: AChR
• Solubility: Water: 44.9 mg/L

Bioactivity

• In Vitro:
  HERG tail currents recorded at -40 mV following test pulses to +30 mV were inhibited in a dose-dependent fashion by Disopyramide concentrations within the clinical range (IC50 = 7.23 μM).
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

AChR