Dirozalkib

SKU: orb3028827

Description

Dirozalkib (Compound 4) is an ALK inhibitor with an IC50 of 0.9 nM. It demonstrates antiproliferative activity in cancer cells NCI-H3122, Karpas-299, and NCI-H2228, with IC50 values of 130.4, 0.71, and 15.11 nM, respectively. Dirozalkib exhibits favorable pharmacokinetic properties and a bioavailability ranging from 30% to 50%.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 1893419-37-8
• MW: 558.092
• Formula: C₂₇H₃₂ClN₅O₄S
• SMILES: O=S(=O)(C=1C=CC=CC1NC2=NC(=NC=C2Cl)NC=3C=C(C(=C4OCCOC43)C5CCNCC5)C)C(C)C
• Target: ALK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

ALK