Dipyrithione

SKU: orb1299339

Description

Dipyrithione is a small molecule exhibiting potent and broad-spectrum antitumor activity through a novel cytotoxic mechanism. It has demonstrated efficacy in both in vitro cell culture studies and in vivo animal models across various cancer research fields.

Research Area

Cell Biology, Infectious Disease & Virology

Key Properties

• CAS Number: 3696-28-4
• MW: 252.31
• Purity: 99.90% (May vary between batches)
• Formula: C₁₀H₈N₂O₂S₂
• SMILES: [O-][n+]1ccccc1SSc1cccc[n+]1[O-]
• Target: Apoptosis,Others,Antibacterial,Antifungal
• Solubility: DMSO:2.53 mg/mL (10.03 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.96 mM)

Bioactivity

• In Vitro:
  Dipyrithione(PTS2) inhibited proliferation in four cancer cell lines in a dose-dependent manner. Treated cells showed shrinkage, irregular fragments, condensed and dispersed blue fluorescent particles compared with control cells. PTS2 induced cycle-arrest and death. Cleavage of caspase-9, caspase-3, and PARP were detected in PTS2-treated cells. Antitumor activity of PTS2 was more effective against widely used cancer drugs and its precursor.
• Cell Research:
  Used MTT assays and trypan blue staining to test the viability of cancer cell lines. Hoechst 33258 and DAPI staining were used to observe cell apoptosis. Cell-cycle percentages were analyzed by flow cytometry. Apoptosis was assayed using caspase-3 and poly (ADP-ribose) polymerase (PARP) combined with Western blotting. Student's t-test was used for statistical analysis.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

dermatophytosis, Dipyrithione, Apoptosis, anti-tumor, antiproliferative, antifungal, anti-inflammatory, Bacterial, G1 phase, Fungal, Inhibitor, inhibit

Compound Identifiers

PubChem CID

3109