Diphyllin

SKU: orb1297554

Description

Diphyllin is a novel V-ATPase inhibitor with research applications in gastric cancer. It suppresses tumor cell growth by inhibiting the Wnt/β-catenin pathway via blocking LRP6 phosphorylation, as demonstrated in in vitro studies.

Research Area

Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry

Key Properties

• CAS Number: 22055-22-7
• MW: 380.35
• Purity: 99.98% (May vary between batches)
• Formula: C₂₁H₁₆O₇
• SMILES: COc1cc2c(O)c3COC(=O)c3c(-c3ccc4OCOc4c3)c2cc1OC
• Target: Influenza Virus,HIV Protease,ATPase,Proton pump
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM);DMSO:3.81 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  HIV-1:0.38 μM (IC50)|H+-ATPase (vacuolar type):17 nM (IC50)
• In Vitro:
  The in vitro inhibitory effects of these compounds were evaluated on the production of nitric oxide (NO) and cytokines (tumor necrosis factor (TNF)-alpha and interleukin (IL)-12), from LPS/IFN-gamma activated murine peritoneal macrophages. The results indicated that the 50% inhibition concentration (IC(50)) values of NO production from activated peritoneal macrophages by compounds 1-4 were 100, 25, 12.5 and 50 microM, respectively. In parallel, these dilutions were approximately inhibited in a similar manner to that observed for cytokines (TNF-alpha, and IL-12) production. On the other hand, at 100 microM concentration compounds 3 and 4 showed 50% inhibition of NO production from peritoneal macrophages that had been pre-activated with LPS/IFN-gamma for 24h, whereas compounds 1 and 2 inhibited only about 20 and 10%, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Protonpump, Proton Pump, Proton pump, Wnt/β-catenin, Vesicular stomatitis virus (VSV), Vacuolar type H+-ATPase, VSV, virus, cytotoxicity, Diphyllin, c-Myc, antiviral, arylnaphthalene, ATPase, lignan, inhibit, influenza, InfluenzaVirus, Influenza Virus, Inhibitor, HIV, HIVProtease, HIV Protease, HIV-1, Human immunodeficiency virus

Compound Identifiers

PubChem CID

100492