Diphenmanil methylsulfate

SKU: orb1310460

Description

Diphenmanil methylsulfate is a quaternary ammonium antimuscarinic agent that inhibits acetylcholine at muscarinic receptors. It is used in research to study the modulation of gastric acid, sweat, and salivary secretion in both in vitro receptor assays and in vivo physiological studies.

Research Area

Neuroscience

Key Properties

• CAS Number: 62-97-5
• MW: 389.51
• Purity: 99.85%
• Formula: C₂₀H₂₄N·CH₃O₄S
• SMILES: COS([O-])(=O)=O.C[N+]1(C)CCC(CC1)=C(c1ccccc1)c1ccccc1
• Target: AChR
• Solubility: Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:26 mg/mL (66.75 mM);DMSO:50 mg/mL (128.37 mM)

Bioactivity

• In Vivo:
  Diphemanil Methylsulfate exerts its anticholinergic effects primarily by binding to muscarinic M3 receptors, and it also acts directly on smooth muscle to provide antispasmodic benefits.
• In Vitro:
  Pharmacokinetic studies indicate that Diphemanil Methylsulphate is slowly absorbed, with a peak time (tmax) of 2-4 hours and an average half-life of 8.35 hours. Within 48 hours, 0.6%-7.4% of the administered dose is recovered in the urine. The compound exhibits poor gastrointestinal absorption, with bioavailability ranging from 15% to 25%.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diphenmanil, Diphenmanil methylsulfate, Diphemanil, Diphemanil mesylate, Diphemanil Mesylate, Diphemanil Methylsulfate, AChR, Muscarinic acetylcholine receptor, inhibit, mAChR, Inhibitor

Compound Identifiers

PubChem CID

6126