Dinoprost Tromethamine

SKU: orb1222301

Description

Dinoprost Tromethamine, also known as Dinoprost Trometamol, is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.(In Vitro):Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells.Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 38562-01-5
• MW: 475.62
• Purity: >98% (HPLC)
• Formula: C₂₄H₄₅NO₈
• SMILES: NC(CO)(CO)CO.CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O
• Target: PEG
• Solubility: H2O : ≥ 4.8 mg/mL; 10.09 mM

Bioactivity

• In Vitro:
  Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells. Dinoprost tromethamine salt (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors. Apoptosis Analysis Cell line: Goat luteal cells. Concentration: 1 μM. Incubation time: For 24 hours. Result: Significantly increased the apoptotic rate (15.62±3.12%). Cell Autophagy Assay Cell line: Goat luteal cells. Concentration: 1 μM. Incubation time: For 24 hours. Result: There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells. Western blot analysis. Cell line: Goat luteal cells. Concentration: 1 μM. Incubation time: For 24 hours. Result: The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

U 14585 | U14585 | U-14585 | Dinoprost Tromethamine

Quick Database Links

Gene Symbol

PEG