Dimethyloxaloylglycine

SKU: orb1223729

Description

DMOG is an antagonist of α-ketoglutarate cofactor and inhibitor for HIF prolyl hydroxylase.(In Vitro):DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.(In Vivo):DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.

Key Properties

• CAS Number: 89464-63-1
• MW: 175.14
• Purity: >98% (HPLC)
• Formula: C₆H₉NO₅
• SMILES: O=C(OC)CNC(C(OC)=O)=O
• Target: HIF/HIF Prolyl-hydroxylase
• Solubility: Soluble in DMSO

Bioactivity

• In Vivo:
  DMOG inhibits endogenous HIF inactivation, and induces angiogenesis in ischaemic skeletal muscles of mice. Up-regulation of hypoxia-inducible factor-1α by DMOG enhances the cardioprotective effects of ischemic postconditioning in hyperlipidemic rats.
• In Vitro:
  DMOG efficiently suppresses hydroxyproline synthesis in intact cells, but shows only weakly active in the microsomal system. DMOG reduces FGF-2-induced proliferation and cyclin A expression by inhibiting prolyl hydroxylase activity in HPASMC.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DMOG

Quick Database Links

Gene Symbol

HIF/HIF Prolyl-hydroxylase