Dimethylenastron

SKU: orb1304518

Description

Dimethylenastron is a cell-permeable Eg5 kinesin inhibitor used in cell biology research. It induces mitotic arrest by generating monopolar spindles with syntelic chromosome attachments, a valuable phenotype for studying mitosis and antimitotic mechanisms in vitro.

Research Area

Signal Transduction

Key Properties

• CAS Number: 863774-58-7
• MW: 302.39
• Purity: 98.07%
• Formula: C₁₆H₁₈N₂O₂S
• SMILES: O=C1C=2C(NC(=S)NC2CC(C)(C)C1)C3=CC(O)=CC=C3
• Target: Kinesin
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.61 mM);DMSO:55 mg/mL (181.88 mM)

Bioactivity

• Target IC50:
  EG5:200 nM.
• In Vitro:
  Dimethylenastron (DMN) inhibits the growth of LECs and HUVECs in a dose- and time-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Eg5, Kinesin, inhibit, Dimethylenastron

Compound Identifiers

PubChem CID

11609157