Dimethyl bisphenolate

SKU: orb3174274

Description

Dimethyl bisphenolate (Compound DMB) is a novel natural lignan derivative with oral antitumor activity. It inhibits cancer cell proliferation, invasion, and migration. Dimethyl bisphenolate activates the p53 signaling pathway, upregulates the expression of p21 protein, and suppresses the activity of the CDK1-cyclin B1 complex, causing cell cycle arrest in the G2/M phase. Additionally, it induces the production of reactive oxygen species (ROS), upregulates pro-apoptotic proteins Noxa and Bim, downregulates anti-apoptotic protein Bcl-2, activates caspase-9 and caspase-3, ultimately leading to apoptosis. Dimethyl bisphenolate is applicable in glioblastoma research.

Research Area

Cell Biology, Immunology & Inflammation, Protein Biochemistry

Key Properties

• Target: CDK,MDM-2/p53,ROS,Bcl-2 Family,Apoptosis,Caspase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,MDM-2/p53,ROS,Bcl-2 Family,Apoptosis,Caspase