Dimethyl biphenyl-4,4'-dicarboxylate

SKU: orb1301365

Description

Dimethyl biphenyl-4,4'-dicarboxylate is a planar ester compound investigated for its hepatoprotective properties. Research in models of chronic hepatitis explores its potential therapeutic applications in both in vitro and in vivo experimental settings.

Key Properties

• CAS Number: 792-74-5
• MW: 270.28
• Purity: 98.37% (May vary between batches)
• Formula: C₁₆H₁₄O₄
• SMILES: C(OC)(=O)C1=CC=C(C=C1)C2=CC=C(C(OC)=O)C=C2
• Target: Others
• Solubility: DMSO:Insoluble;H2O:2.5 mM

Bioactivity

• In Vivo:
  Pretreatment with DDB (300 mg/kg) orally could ameliorate the reduction of liver glycogen and blood glucose caused by injection of D-gal (800 mg/kg i. p) in mice. When normal rats received 300 mg/kg of DDB once daily for 10 days, free ribosomal protein and RNA in the liver increased significantly.
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• In Vitro:
  Dimethyl biphenyl-4,4'-dicarboxylate(DDB) (200 ug/10(6) cells) efficiently protected the hepatocytes against carbon tetrachloride (10 mM) and D-galactosamine (1 mM) induced damages. Membrane lipid peroxidation (malondialdehyde, MDA) formation and Glutamic Pyruvic Transaminase (GPT) released from the hepatocytes were markedly decreased. The damage of the cell surfaces of the hepatocytes were also reduced as seen under a scanning electron microscope (SEM).
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Biphenyl dimethyl dicarboxylate, Dimethyl biphenyl 4,4' dicarboxylate, Dimethyl biphenyl-4,4'-dicarboxylate, Dimethyl biphenyl4,4'dicarboxylate, inhibit, Inhibitor

Compound Identifiers

PubChem CID

13099