DIM-C-pPhOCH3

SKU: orb1222351

Description

DIM-C-pPhOCH3 is a Nur77 agonist. It has been shown to induce apoptosis in cancer cell lines and long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse mode.

Key Properties

• CAS Number: 33985-68-1
• MW: 352.44
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₀N₂O
• SMILES: COc1ccc(cc1)C(c3cnc2ccccc23)c5cnc4ccccc45
• Target: Nur77
• Solubility: DMSO : ≥ 33.3 mg/mL; 94.49 mM

Bioactivity

• In Vivo:
  DIM-C-pPhOCH3 (25 mg/kg/d) also inhibits tumor growth in athymic nude mice bearing RKO cell xenografts. The effects of DIM-C-pPhOCH3 (25 mg/kg/d) on colon tumor growth are also investigated in athymic nude mice bearing RKO cell xenografts. Treatment with the DIM-C-pPhOCH3 significantly decreases tumor volumes and final tumor weights compared with corn oil controls.
• In Vitro:
  DIM-C-pPhOCH3 decreases survival and induces apoptosis in RKO colon cancer cells, and this is accompanied by induction of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) protein. DIM-C-pPhOCH3 also induces Nur77-independent apoptosis. DIM-C-pPhOCH3 (10 μM) inhibits cell growth after treatment for 24, 48, or 72 h, and the maximum inhibitory response is observed after 72 h, where there is considerable cell detachment and dead cells. The growth-inhibitory effects observed for DIM-C-pPhOCH3 after 72 h are also accompanied by several markers of apoptosis, including PARP cleavage and cleavage of caspase-3, caspase-9, and caspase-8. PARP cleavage is also observed after treatment of RKO cells for 48 h with DIM-C-pPhOCH3.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DIM-C-pPhOCH3 | DIM C pPhOCH3 | DIM-C-pPhOMe

Quick Database Links

Gene Symbol

Nur77