DIM-3,5-Cl2

SKU: orb3173874

Description

DIM-3,5-Cl2 is an inverse agonist of NR4A1 (KD = 7.7 μM) and NR4A2 (KD = 12.0 μM) and possesses bidirectional regulatory functions. As an inverse agonist, DIM-3,5-Cl2 suppresses the expression of targets that promote cancer and endometriosis; as an agonist, it enhances NR4A1/2-mediated transcriptional activation of CD71 in cooperation with Sp1/Sp4. DIM-3,5-Cl2 induces tumor cell death through two lethal signaling pathways: one relies on elevated ROS, exacerbated lipid peroxidation, and MDA accumulation, along with inhibition of GPX4/SLC7A11 to trigger ferroptosis; the other induces apoptosis via cleavage-mediated activation of PARP/caspase-3 and downregulation of BCL-2.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research

Key Properties

• CAS Number: 2595179-74-9
• MW: 391.30
• Purity: 99.89% (May vary between batches)
• Formula: C₂₃H₁₆Cl₂N₂
• SMILES: ClC=1C=C(Cl)C=C(C1)C(C2=CNC=3C=CC=CC32)C4=CNC=5C=CC=CC54
• Target: NR4A,Ferroptosis,ROS,Glutathione Peroxidase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

NR4A,Ferroptosis,ROS,Glutathione Peroxidase