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Dilmapimod

SKU: orb1218023

Description

Dilmapimod is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease.

Images & Validation

Key Properties

CAS Number444606-18-2
MW456.42
Purity>98% (HPLC)
FormulaC23H19F3N4O3
SMILESCc(cc(cc1)F)c1-c1c(C=CC(N2c(c(F)ccc3)c3F)=O)c2nc(NC(CO)CO)n1
TargetAutophagy
SolubilityDMSO:125 mg/mL (273.87 mM; Need ultrasonic)

Bioactivity

In Vitro
Dilmapimod (SB-681323) potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

SB-681323 | GW 681323

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Protocol Information

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5 mg
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