Dihydromyricetin

SKU: orb1304756

Description

Dihydromyricetin (Ampelopsin) is a flavonoid antioxidant isolated from Ampelopsis grossedentata. It acts as a dihydropyrimidinase inhibitor (IC50 = 48 µM) and an mTOR-dependent autophagy inducer, making it a useful research tool for studying metabolic regulation and cellular clearance pathways in vitro and in vivo.

Research Area

Cell Biology, Infectious Disease & Virology, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 27200-12-0
• MW: 320.25
• Purity: 98.23% (May vary between batches)
• Formula: C₁₅H₁₂O₈
• SMILES: O[C@@H]1[C@H](Oc2cc(O)cc(O)c2C1=O)c1cc(O)c(O)c(O)c1
• Target: DNA/RNA Synthesis,Influenza Virus,mTOR,GABA Receptor,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.61 mM);Ethanol:60 mg/mL (187.35 mM);DMSO:242 mg/mL (755.66 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  mTOR:48 μM
• In Vivo:
  Dihydromyricetin (1 μM), as an innovative anti-alcohol intoxication agent, antagonizes acute ethanol-induced enhancements in GABA(A)Rs, as well as increases in GABA(A)R plasticity and expression of the GABA(A)R α4 subunit in the hippocampus and cultured neurons due to ethanol exposure/withdrawal. Additionally, Dihydromyricetin effectively scavenges DPPH radicals and inhibits the increase in lipid peroxidation catalyzed by FeSO4 and ethylenediaminetetraacetic acid in the linoleic acid system.
• In Vitro:
  Intraperitoneal injection of 1 mg/kg Dihydromyricetin in rats neutralizes the symptoms of acute alcohol intoxication and eliminates signs of increased tolerance, heightened anxiety, and susceptibility to convulsions. The LD50 for intraperitoneal injection in mice is 1.41 g/kg.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNASynthesis, DNA/RNA Synthesis, DNA Synthesis, Dihydromyricetin, Ampeloptin, Ampelopsin, Autophagy, mTOR, Influenza Virus, InfluenzaVirus, inhibit, GABA Receptor, GABAR, GABAReceptor, Inhibitor, Mammalian target of Rapamycin, RNA Synthesis, RNASynthesis

Compound Identifiers

PubChem CID

161557