Dihydroevocarpine

SKU: orb2943141

Description

Dihydroevocarpine is a small molecule that induces cytotoxicity, apoptosis, and cell cycle arrest in acute myeloid leukemia (AML) cells. It functions as a dual mTORC1/2 inhibitor, suppressing the mTOR pathway to impede tumor growth in both in vitro assays and in vivo xenograft models for AML research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 15266-35-0
• MW: 341.53
• Purity: 99.82% (May vary between batches)
• Formula: C₂₃H₃₅NO
• SMILES: O=C1C=C(N(C=2C=CC=CC12)C)CCCCCCCCCCCCC
• Target: mTOR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.93 mM);DMSO:10 mg/mL (29.28 mM)

Bioactivity

• Target IC50:
  CEM/ADR5000 cells:33.14 μM|CCRF-CEM cells:14.08 μM
• In Vivo:
  BALB/C nude mice bearing subcutaneous HL-60 leukemia cells were treated with intraperitoneal injections of Dihydroevocarpine (10 mg/kg/day) for 20 days, resulting in a significant antitumor effect.
• In Vitro:
  Dihydroevocarpine exhibits moderate in vitro cytotoxicity against CCRF-CEM and CEM/ADR5000 leukemia cell lines, with IC₅₀ values of 14.08 μM and 33.14 μM, respectively.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dihydroevocarpine, 1-methyl-2-tridecylquinolin-4-one, Antifection, MAO, P-gp, Pgp

Compound Identifiers

PubChem CID

5322031