Dihomo-γ-linolenic acid

SKU: orb1679007

Description

Dihomo-γ-linolenic acid (DGLA) is a plant-derived fatty acid with demonstrated antiproliferative and antitumor properties, inhibiting xenograft tumor growth in vivo. Its role in modulating inflammatory pathways supports research in areas such as rheumatoid arthritis, atherosclerosis, and atopic dermatitis.

Research Area

Metabolism Research

Key Properties

• CAS Number: 1783-84-2
• MW: 306.48
• Purity: 98.10%
• Formula: C₂₀H₃₄O₂
• SMILES: CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O
• Target: Endogenous Metabolite
• Solubility: DMSO:80 mg/mL (261.03 mM);Ethanol:100 mg/mL (326.29 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.77 mM)

Bioactivity

• In Vivo:
  In 48 four-week-old female nude mice, administration of 8 mg per mouse via oral gavage twice a week for 35 days suppressed the metastatic potential of D5D-KD tumors.
• In Vitro:
  In THP-1 macrophages, Dihomo-γ-linolenic acid (50 μM; 24 hours) attenuates IFN-γ-induced phosphorylation of STAT1 at serine 727.

Storage & Handling

• Storage: store at low temperature,keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, all-cis-8,11,14-Eicosatrienoic acid, Dihomo γ linolenic acid, Dihomo-gamma-linolenic acid, Dihomo-r-linolenic acid, Dihomoγlinolenic acid, Dihomo-γ-linolenic acid, Diroleuton, Ro 12-1989

Compound Identifiers

PubChem CID

5280581