Diethylmaleate

SKU: orb1306337

Description

Diethylmaleate is the diethyl ester of maleic acid, functioning as a glutathione-depleting agent and NF-kB inhibitor. It is widely used in research to study oxidative stress, inflammation, and cell signaling pathways in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 141-05-9
• MW: 172.18
• Purity: 96.53%
• Formula: C₈H₁₂O₄
• SMILES: C(/C=C\C(OCC)=O)(OCC)=O
• Target: NF-κB
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:8 mg/mL (46.46 mM);DMSO:60 mg/mL (348.47 mM)

Bioactivity

• In Vivo:
  In TR- rats, in spite of a dilatation of the Golgi apparatus and of the endoplasmic reticulum. It is unlikely that the alterations in the Golgi apparatus (and the endoplasmic reticulum) induced by diethylmaleate play a role in the canalicular secretion of diethylmaleate.
• In Vitro:
  Diethylmaleate and iodoacetate in combination caused augmented damage to astrocytes in a time- and concentration-dependent manner.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diethylmaleate, Diethyl, DIETHYL MALEATE, DIETHYL Maleate, Inhibitor, Maleic acid, diethyl ester, glutathione, GSH, NF-κB, NFkB, NFκB, NF-kB, inhibit

Compound Identifiers

PubChem CID

5271566