Didymin

SKU: orb1222701

Description

Didymin has antioxidant property. Didymin induces apoptosis by inhibiting N-Myc and upregulating RKIP in neuroblastoma, may used for neuroblastoma therapy. Didymin may be a potential therapeutic molecule for the treatment of neurodegenerative disorders associated with oxidative stress.

Key Properties

• CAS Number: 14259-47-3
• MW: 594.57
• Purity: >98% (HPLC)
• Formula: C₂₈H₃₄O₁₄
• SMILES: C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)Oc1cc(c2C(=O)C[C@H](Oc2c1)c1ccc(cc1)OC)O)O)O)O)O)O)O
• Target: Others
• Solubility: In Vitro: DMSO : 250 mg/mL (420.48 mM)

Bioactivity

• In Vivo:
  Animal model: Male nude mice [6 weeks old; BALB/cA-nu (nu/nu)] injected with A549 cells. Dosage: 6 mg/kg/day. Administration: i.p.; daily for 28 days. Result: Inhibited tumor growth in nude mice.
• In Vitro:
  Cell Proliferation Assay Cell line: A549 and H460 cells. Concentration: 1 μM, 5 μM, 10 μM, 20 μM. Incubation time: 48 h. Result: Inhibited cell proliferation in human non-small-cell lung cancer cells. Apoptosis Analysis Cell line: A549 and H460 cells. Concentration: 10 μM, 20 μM. Incubation time: 12 h, 24 h, 48 h. Result: Induced apoptosis in A549 and H460 cells, without affecting the cell cycle distribution.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

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